Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
L-Proline, 1-[(2S)-2-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-oxo-8-nonen-1-yl]-4-hydroxy-, (4R)-, also named (2S,4R)-4-hydroxy-1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]non-8-enoyl]pyrrolidine-2-carboxylic acid, is a useful chemical compound.
Macrocyclic peptides are disclosed havin...
Macrocyclic peptides are disclosed havin...
Macrocyclic peptides having the general ...
L-4-hydroxyproline methyl ester hydrochloride
1-(2(S)-tert-butoxycarbonylamino-non-8-enoyl)-4(R)-hydroxy-pyrrolidine-2(S)-carboxylic acid
| Conditions | Yield |
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Multi-step reaction with 2 steps
1: 4-methyl-morpholine; HATU / dichloromethane / 72 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C
With 4-methyl-morpholine; lithium hydroxide; water; HATU; In tetrahydrofuran; methanol; dichloromethane;
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Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; HATU / dichloromethane / 72 h / 20 °C
2.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C
2.2: pH 4
With 4-methyl-morpholine; lithium hydroxide; water; HATU; In tetrahydrofuran; dichloromethane;
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1-(2(S)-tert-butoxycarbonylamino-non-8-enoyl)-4(R)-hydroxy-pyrrolidine-2(S)-carboxylic acid
C32H44N4O8S
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 8 steps
1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C
3.1: tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride / dichloromethane / 0.25 h / Heating / reflux
4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C
4.2: pH 4
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating / reflux
5.2: 4 h / 20 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
7.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C
8.1: MgBr2*Et2O / tetrahydrofuran / 3 h / 0 °C / Cooling with acetone-dry ice
With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; MgBr2*Et2O; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; HATU; 1,1'-carbonyldiimidazole; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
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L-4-hydroxyproline methyl ester hydrochloride
(1R,2S)-ethyl 1-((2S,4R)-1-((S)-2-(((tert-butoxy)carbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate
tert-butyl (2R,6S,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-hydroxy-5,16-dioxo-1,2,3,5,6,7,8, 9,10,11,13a,14,14a,15,16,16a-hexadecahydronaphthylcyclopropanoyl[e]pyrrolo[1,2-a][1,4]diazacyclopenta decyne-6-yl-carbamate
C32H44N4O8S
C38H48N4O8S
