is Solid powder, while it's Molecular Formula is C26H31ClN6O2. Solid powder

What is the CAS number for ?

The CAS number of is 1508250-71-2.

What is (1508250-71-2) used for?

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.

is Solid powder, while it's Molecular Formula is C26H31ClN6O2. Solid powder

What is the CAS number for ?

The CAS number of is 1508250-71-2.

What is (1508250-71-2) used for?

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.

1508250-71-2

английское имя：EGF816
Брутто-формула：C26H31ClN6O2
Степень чистоты：99%
Молярная масса：495.02

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информация о продукте

CAS номер： 1508250-71-2

Брутто-формула： C26H31ClN6O2

Внешний вид： Solid powder

также известно как . представлено символом C26H31ClN6O2, который состоит из 26 атомов Углерод,31 атомов Водород,1 атома Хлор,6 атомов Азот и 2 атомов Кислород..

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