1235403-62-9

Q: What is the CAS number for 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamideMolecular Weight: 500.35?

The CAS number of 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamideMolecular Weight: 500.35 is 1235403-62-9.

Q: What is 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamideMolecular Weight: 500.35 (1235403-62-9) used for?

PF-05089771 (1235403-62-9) is a potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3? It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 μM for resting channels.1? Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2

Product Name：4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
Molecular Formula：
Purity：99%
Molecular Weight：500.361

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Product Details

CasNo： 1235403-62-9

Buy High Grade Top Purity 99% 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide 1235403-62-9 Cheap Price

Molecular Formula:C₁₈H₁₂Cl₂FN₅O₃S₂
Molecular Weight:500.361
Boiling Point:699.5±65.0 °C(Predicted)
PKA:5.58±0.40(Predicted)
Density:1.673±0.06 g/cm3(Predicted)

1235403-62-9 Relevant articles

Cycloalkyl-substituted mesyl benzamide derivatives, and preparation method and medical application thereof

-

Paragraph 0130; 0131; 0143, (2017/08/25)

The invention relates to cycloalkyl-subs...

1235403-62-9 Process route

: C₂₃H₂₀Cl₂FN₅O₅S₂

: 1235403-62-9,1430806-03-3
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

Conditions

Conditions	Yield
With trifluoroacetic acid; In dichloromethane; at 20 - 25 ℃; for 24h; Inert atmosphere;	31%

: 13656-57-0
5-chloro-2,4-difluorobenzene-1-sulfonyl chloride

: 1235403-62-9,1430806-03-3
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 - 25 °C / Inert atmosphere 1.2: 17 h / -78 - 25 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 - 25 °C / Inert atmosphere With potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Yield

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 - 25 °C / Inert atmosphere

1.2: 17 h / -78 - 25 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 - 25 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

1235403-62-9 Upstream products

13656-57-0
5-chloro-2,4-difluorobenzene-1-sulfonyl chloride
33924-48-0
methyl 5-chloro-2-methoxybenzoate
7035-10-1
(5-chloro-2-methoxyphenyl)methanol
7048-38-6
(5-chloro-2-methoxy-phenyl)-acetonitrile

1235403-62-9 Downstream products

1430806-04-4
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide tosylate

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