is Solid powder, while it's Molecular Formula is C26H31ClN6O2. Solid powder

What is the CAS number for ?

The CAS number of is 1508250-71-2.

What is (1508250-71-2) used for?

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.

is Solid powder, while it's Molecular Formula is C26H31ClN6O2. Solid powder

What is the CAS number for ?

The CAS number of is 1508250-71-2.

What is (1508250-71-2) used for?

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.

1508250-71-2

英語名：EGF816
化学分子式：C26H31ClN6O2
純度：99%
分子量：495.02

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製品詳細

CAS番号： 1508250-71-2

化学分子式： C26H31ClN6O2

外観： Solid powder

は、としても知られています。であるはC26H31ClN6O2という記号であらわされますが、これは炭素原子26個、水素原子31個、塩素原子1個、窒素原子6個、酸素原子2個からできています。

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1508250-71-2

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